Key result
Intramuscular digoxin linked to fatal ventricular arrhythmias driven by focal myocardial lesions.
Case Report (n=1)
Describes a fatal case of ventricular arrhythmias in a child associated with unique focal myocardial degeneration.
Alerts clinicians to rare focal myocardial lesions in fatal infant arrhythmias; leaves open etiology and detection strategies.
A 16-month-old child died with ventricular arrhythmias associated with peculiar focal myocardial lesions characterized by myofilament dissolution and mitochondrial hyperplasia.Case ReportA 16-month-old girl (J.H.H. 141 06 28) was in excellent health until a 4-hour episode of rapid pulse, vomiting, cyanosis and pallor occurred. A similar episode occurred 1 week later. An electrocardiogram was interpreted as showing supraventricular tachycardia (rate of 320 per minute). Carotid-sinus massage was unsuccessful, but sinus rhythm was restored 4 hours after intramuscular digoxin (45 μg per kilogram of body weight). On the next day ventricular bigeminy was followed by tachycardia, which responded to 5 . . .
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Haese et al. (1972) conducted a case report in Ventricular arrhythmias and focal myocardial degeneration (n=1). Focal myocardial degeneration was evaluated on Death due to ventricular arrhythmias. A 16-month-old girl died from ventricular arrhythmias associated with peculiar focal myocardial lesions characterized by myofilament dissolution and mitochondrial hyperplasia.
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