Key result
Buprenorphine added to lignocaine extends postoperative analgesia ~36% vs dexmedetomidine and hastens blockade onset.
Why the study?
Many drugs are used as adjuvants to local anaesthetics to improve anaesthesia quality, but the comparative effects of adding buprenorphine versus dexmedetomidine to lignocaine with adrenaline in supraclavicular brachial plexus block were evaluated.
Does buprenorphine compared to dexmedetomidine improve block characteristics and analgesia duration in patients undergoing forearm surgeries under supraclavicular brachial plexus block?
RCT (n=80)
Randomized
No
Does buprenorphine compared to dexmedetomidine improve block characteristics and analgesia duration in patients undergoing forearm surgeries under supraclavicular brachial plexus block?
Absolute Event Rate: 420% vs 308.5%
p-value: p=0.002
Buprenorphine is a superior adjuvant to dexmedetomidine for supraclavicular brachial plexus block, providing faster onset and longer duration of sensory and motor blockade and postoperative analgesia.
May support buprenorphine over dexmedetomidine for longer block analgesia; leaves open confirmation in larger randomized trials.
Background: Supraclavicular brachial plexus block is the most commonly employed regional anaesthesia technique for upperlimb surgeries below elbow joint. Many drugs are used as adjuvants to local anaesthetics in order to extend and improve the quality of intraoperative and postoperative anaesthesia. We conducted a study to compare the effects of adding Buprenorphine vs Dexmedetomidine to intermediate-acting local anaesthetic 2% lignocaine with adrenaline in supraclavicular brachial plexus block. Aims and objectives: To compare the effects of adding Buprenorphine vs Dexmedetomidine to 2% lignocaine with adrenaline (1 in 200000) in patients undergoing forearm surgeries under supraclavicular brachial plexus block in terms of onset and duration of sensory and motor blockade, as well as the duration of postoperative analgesia. Materials and methods: 80 ASA Grade 1 & 2 patients aged between 18 and 60 years, of both sexes, undergoing forearm surgeries under supraclavicular brachial plexus block were divided into 2 groups of 40 each. Group A received 7mg/kg of 2% lignocaine with adrenaline + Buprenorphine 3µg/kg. Group B received 7mg/kg of 2% lignocaine with adrenaline (1 in 200000)+ Dexmedetomidine(1µg/kg).
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Sreelakshmi et al. (2022) conducted an RCT in Forearm surgeries under supraclavicular brachial plexus block (n=80). Buprenorphine vs. Dexmedetomidine (1µg/kg) was evaluated on Duration of postoperative analgesia (minutes) (p=0.002). Buprenorphine added to lignocaine significantly prolonged the mean duration of postoperative analgesia (420.0 vs 308.5 minutes) and hastened the onset of sensory and motor blockade compared to dexmedetomidine.
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