Key result
Coronary artery diameters correlate with body metrics, making the square root model optimal for Z-scores.
Why the study?
Coronary artery distension and aneurysm are complications of Kawasaki disease in children, motivating the development of a reference Z-score regression model for coronary artery diameter.
Observational (n=509)
The square root model provides an optimal equation for calculating coronary artery Z-scores in Chinese Han children, facilitating the diagnosis of coronary artery distension in suspected Kawasaki disease.
Answers are grounded in this paper and cite their sources.
May aid Z-score standardization in Chinese Han children; leaves open validation before wider clinical use.
Background Coronary artery distension and aneurysm are complications of Kawasaki disease in children. Purpose To develop a Z-score regression model for coronary artery diameter in children that could be used as reference. Material and Methods This retrospective analysis included children with normal heart structure between March 2013 and April 2017. Body surface area (BSA) was calculated. The diameters of the right coronary, left main coronary, left anterior descending, and circumflex arteries were measured by echocardiography. Pearson correlation analysis was used to establish linear, exponential, logarithmic, power, and square root regression models. Results The analysis included 509 children (280 boys) aged 1 day to 15.2 years. Coronary artery diameters were significantly correlated with age, height, body mass, BSA, and [Formula: see text] (r = 0.663–0.826; P < 0.05), with a stronger correlation for [Formula: see text] than BSA ( P < 0.05). The adjusted determination coefficients ([Formula: see text]) were higher for the exponential and square root models than for the other models ( P < 0.05). The random error term variance was constant for the exponential model ( P > 0.05), and processing with the weighted least-square methods eliminated heteroscedasticity in the other models. The Z-scores were normally distributed for the exponential and square root models ( P > 0.05). Conclusion Overall, the square root model was the optimal equation for the calculation of coronary artery Z-score in Chinese Han children. This model could be used to facilitate the diagnosis of coronary artery distension in children with suspected Kawasaki disease.
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Yang et al. (2022) conducted an observational in Normal heart structure (n=509). Body metrics (age, height, body mass, BSA) was evaluated on Correlation of coronary artery diameters with body metrics (r = 0.663-0.826, p=<0.05). Coronary artery diameters were significantly correlated with body metrics (r = 0.663–0.826; P < 0.05), and the square root model was the optimal equation for calculating Z-scores.
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