Key result
Computational modeling of the human aorta demonstrated a strong positive correlation (r > 0.93) between wall shear stress and nitric oxide concentration, with reduced NO bioavailability in regions of disturbed flow.
Computational modeling demonstrates that local hemodynamics and wall shear stress strongly influence nitric oxide distribution in the human aorta, which may explain the localization of vascular diseases.
Answers are grounded in this paper and cite their sources.
Local hemodynamics may shape NO distribution in atherosclerosis-prone arteries; leaves open causal role in disease localization.
Despite the crucial role of nitric oxide (NO) in the homeostasis of the vasculature, little quantitative information exists concerning NO transport and distribution in medium and large-sized arteries where atherosclerosis and aneurysm occur and hemodynamics is complex. We hypothesized that local hemodynamics in arteries may govern NO transport and affect the distribution of NO in the arteries, hence playing an important role in the localization of vascular diseases. To substantiate this hypothesis, we presented a lumen/wall model of the human aorta based on its MRI images to simulate the production, transport and consumption of NO in the arterial lumen and within the aortic wall. The results demonstrated that the distribution of NO in the aorta was quite uneven with remarkably reduced NO bioavailability in regions of disturbed flow, and local hemodynamics could affect NO distribution mainly via flow dependent NO production rate of endothelium. In addition, erythrocytes in the blood could moderately modulate NO concentration in the aorta, especially at the endothelial surface. However, the reaction of NO within the wall could only slightly affect NO concentration on the luminal surface, but strongly reduce NO concentration within the aortic wall. A strong positive correlation was revealed between wall shear stress and NO concentration, which was affected by local hemodynamics and NO reaction rate. In conclusion, the distribution of NO in the aorta may be determined by local hemodynamics and modulated differently by NO scavengers in the lumen and within the wall.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2014) studied Healthy (n=1). Hemodynamics and NO scavengers (computational simulation) was evaluated on Nitric oxide concentration distribution and correlation with wall shear stress. Computational modeling of the human aorta demonstrated a strong positive correlation (r > 0.93) between wall shear stress and nitric oxide concentration, with reduced NO bioavailability in regions of disturbed flow.
Synapse has enriched 10 related papers. Consider them for comparative context: