Why the study?
Does inhibition of NO synthesis alter the uptake of circulating albumin by the aortic wall near branches in immature and mature rabbits?
Population
Immature and mature rabbits (descending thoracic aortas)
Comparison
N omega-monomethyl-L-arginine added to perfusate vs Control perfusate without NO synthesis inhibitor
Design
Preclinical
Follow-up
7 to 8 minutes
Authors
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NO inhibition alters age-specific aortic albumin uptake in rabbits; leaves open relevance to human endothelial barrier function.
Does inhibition of NO synthesis alter the uptake of circulating albumin by the aortic wall near branches in immature and mature rabbits?
Endogenous nitric oxide determines the mature pattern of albumin transport near aortic branches and helps maintain the barrier function of the immature aortic wall.
Forster et al. (1997) studied this question.
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