Why the study?
Does altered flow via occlusion of intercostal arteries affect the pattern of permeability around aortic branches in rabbits?
Does altered flow via occlusion of intercostal arteries affect the pattern of permeability around aortic branches in rabbits?
The study provides direct evidence that flow determines permeability near arterial branches in mature rabbits, potentially explaining the inverse spatial correlation between shear stress and disease prevalence in adult human arteries.
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Reversed permeability gradients at occluded branches support flow as a regulator in mature rabbits; extends mechanistic models but leaves human translation open.
Staughton et al. (2001) studied this question.
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