Key result
Liposomal bupivacaine provided no analgesic benefit over standard bupivacaine alone for quadratus lumborum blocks in 78 patients undergoing laparoscopic colorectal surgery.
Why the study?
This study evaluated the use of liposomal bupivacaine versus standard bupivacaine alone in quadratus lumborum blocks for laparoscopic colorectal surgery.
Does the addition of liposomal bupivacaine to standard bupivacaine improve analgesia or reduce opioid usage in patients undergoing laparoscopic colorectal surgery?
RCT (n=78)
Does the addition of liposomal bupivacaine to standard bupivacaine improve analgesia or reduce opioid usage in patients undergoing laparoscopic colorectal surgery?
The addition of liposomal bupivacaine to standard bupivacaine for quadratus lumborum blocks in laparoscopic colorectal surgery provides no analgesic benefit over standard bupivacaine alone.
Answers are grounded in this paper and cite their sources.
Recommends against liposomal bupivacaine for quadratus lumborum blocks in colorectal surgery; challenges assumptions of extended analgesia.
Aim: This study evaluated use of liposomal bupivacaine (LB) versus standard bupivacaine (SB) alone in quadratus lumborum (QL) blocks for laparoscopic colorectal surgery. Materials & methods: In this prospective, randomized controlled trial, patients received QL1 blocks with either LB (40 ml 0.125% SB plus 20 ml of LB) or SB (60 ml of 0.25% SB) with 30 ml per side. Opioid usage, pain scores, side effects and other medications were recorded. Results: For 78 patients (38 LB; 40 SB), all parameters were similar between groups, except that the LB group had a higher 48 h need for metoclopramide. Conclusion: LB provided no analgesic benefit over SB alone for QL blocks. Clinical Trials registration number: NCT03702621
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Yeap et al. (2021) conducted an RCT in Laparoscopic colorectal surgery (n=78). Liposomal bupivacaine (LB) vs. Standard bupivacaine alone (60 ml of 0.25% standard bupivacaine, 30 ml per side) was evaluated on Opioid usage, pain scores, side effects and other medications. Liposomal bupivacaine provided no analgesic benefit over standard bupivacaine alone for quadratus lumborum blocks in 78 patients undergoing laparoscopic colorectal surgery.
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