Key result
Closely coupled ventricular extrasystoles increase relative myocardial infarct size by ~142% in dogs.
Why the study?
Does electrically induced ventricular bigeminy increase myocardial infarct size in dogs with acute myocardial infarction?
Does electrically induced ventricular bigeminy increase myocardial infarct size in dogs with acute myocardial infarction?
Absolute Event Rate: 0.58% vs 0.24%
p-value: p=<0.01
In a canine model of acute myocardial infarction, frequent closely coupled ventricular extrasystoles significantly increased infarct size.
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No immediate change to PVC management in human AMI; leaves open whether closely coupled extrasystoles enlarge infarcts in patients.
Nattel et al. (1987) studied Myocardial infarction (n=35). Electrically induced ventricular bigeminy (closely coupled extrasystoles) vs. Control group (no induced extrasystoles) or widely coupled extrasystoles was evaluated on Ratio of myocardial infarct size to the region at risk of infarction (p=<0.01). Electrically induced, closely coupled ventricular extrasystoles significantly increased the ratio of myocardial infarct size to the region at risk compared to control dogs (0.58 vs 0.24; p<0.01).
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