Key result
Activatable IPC-SPIOs show physiological ROS sensitivity and induce antioxidant activity in immune and endothelial cells.
Why the study?
The study was conducted to address diagnostic medicine and severity staging of inflammatory diseases using activatable MRI contrast agents sensitive to reactive oxygen species.
Do activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species and act as an activatable MRI contrast agent in macrophages and endothelial cells?
Do activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species and act as an activatable MRI contrast agent in macrophages and endothelial cells?
IPC-SPIOs demonstrate potential as an activatable MRI contrast agent that is sensitive to ROS and possesses antioxidant properties in immune and endothelial cells.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for ROS-sensitive MRI agents in vascular cells; leaves open in vivo translation and clinical testing.
This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.
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Nwasike et al. (2020) studied Inflammatory diseases. Activatable Superparamagnetic Iron Oxide Nanoparticles (IPC-SPIOs) was evaluated on ROS sensitivity and antioxidant activity. Activatable superparamagnetic iron oxide nanoparticles (IPC-SPIOs) demonstrated sensitivity to physiologically relevant reactive oxygen species and induced antioxidant activity in immune and endothelial cells.
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