Key result
The cardiac extracellular matrix is a dynamic entity, with fibrillin identified as a potential target molecule for understanding and modifying cardiac function in normal and diseased hearts.
The cardiac extracellular matrix is a dynamic entity, and fibrillin represents a potential target molecule for understanding and modifying cardiac function in normal and diseased hearts.
Understanding the regulation of the extracellular matrix of heart is essential to understanding the chronic changes in function in disease states such as hypertension, heart , and diabetes. This understanding relies on overturning the concept that the extracellular matrix of the heart is inert. and colleagues, by showing the presence of fibrillin in rodent hearts and its upregulation in of cardiac fibrosis, have demonstrated the dynamic of the extracellular matrix. Furthermore, they have added a potential target molecule for the understanding and modification of cardiac function in both the normal and diseased heart.
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Lindsay Brown (2005) conducted an editorial in Cardiac fibrosis. The cardiac extracellular matrix is a dynamic entity, with fibrillin identified as a potential target molecule for understanding and modifying cardiac function in normal and diseased hearts.
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