Key result
Direct intra-LITA PDE III inhibitor injection increases graft free flow versus saline and papaverine.
Why the study?
Does direct intra-LITA injection of vasodilators (PDE III-I, papaverine, or ISDN) improve graft free flow compared to saline in patients undergoing primary CABG?
Population
80 patients undergoing first primary coronary artery bypass grafting (CABG)
Comparison
Direct intra-left internal thoracic artery… vs Direct intra-LITA injection of saline
Design
RCT, Randomly separated into four groups
Follow-up
1 minute
Authors
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Supports intra-LITA PDE III inhibitor use to optimize graft flow in CABG; extends vasodilator comparisons with RCT evidence.
RCT (n=80)
Randomized
Does direct intra-LITA injection of vasodilators (PDE III-I, papaverine, or ISDN) improve graft free flow compared to saline in patients undergoing primary CABG?
Direct intra-LITA injection of a PDE III inhibitor is highly effective for increasing graft blood flow and decreasing resistance during CABG surgery.
Katsunori Takeuchi (2004) conducted an RCT in Coronary artery bypass grafting (CABG) (n=80). Phosphodiesterase III inhibitor (PDE III-I) vs. Saline, papaverine hydrochloride, and isosorbide dinitrate (ISDN) was evaluated on Left internal thoracic artery (LITA) graft free flow (GFF) and blood vessel resistance (R). Direct injection of a phosphodiesterase III inhibitor into the left internal thoracic artery significantly increased graft free flow compared to saline and papaverine hydrochloride.
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