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Whole lung irradiation (1,500 rads in 10 fractions) was combined with dactinomycin in the treatment of 17 children with metastatic Wilms's tumor. Seven patients (54%) remained disease-free for at least two years. In addition, liver metastases developed in 2 of these survivors who were effectively treated with surgery, irradiation, and chemotherapy. Our control rate is similar to rates found in the literature, which demonstrates that an aggressive treatment approach for patients with metastatic disease by a multidisciplinary pediatric oncology group is worthwhile.
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Wara et al. (1974) studied this question.
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