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Enantiomerically pure β‐necrodol (1) and its 1‐epimer 16 have been synthesized starting from aldehyde 5. The two key steps are an asymmetric conjugate addtion/Mannich reaction tandem (10→12) and a type‐II‐magnesiumene cyclization/oxidation sequence (14→1 + 16).
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Oppolzer et al. (1986) studied this question.
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