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April 14, 2025SN Comprehensive Clinical MedicineOpen Access

Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study

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Authors

OZObaidullah ZafarSTSüha TürkmenHIHaris Iftikhar

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Overview

Retrospective study demonstrates safe hemoglobin recovery with intravenous iron in severe iron deficiency anemia without transfusion, indicating an effective alternative to blood products.

Key Points

  • To evaluate the efficacy and safety of intravenous iron supplementation in outpatients with severe iron deficiency anemia who refused blood transfusions.
  • Retrospective medical record review of N=84 outpatients (89.3% women, 10.7% men; mean age 35.1 years) with severe iron deficiency anemia (hemoglobin < 7 g/dl) who declined blood transfusion.
  • Patients received intravenous iron therapy and were evaluated for changes in hemoglobin, hematocrit, and ferritin levels, as well as the incidence of adverse complications.
  • Mean hemoglobin levels increased significantly from 6.4 g/dl at baseline to 11.1 g/dl following intravenous iron therapy (p < 0.001).
  • Serum ferritin levels increased and total iron-binding capacity decreased after treatment.
  • No complications, treatment-related morbidity, or mortality were reported among treated patients.

Cite This Study

Zafar et al. (2025) studied this question.

synapsesocial.com/papers/6aa3c28562d1fdab09554e18https://doi.org/10.1007/s42399-025-01840-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative effects of parenteral iron therapy in stable iron deficiency anemia with mild vs severe anemia2026
  2. 2Efficacy Of Intravenous Therapy In Children With Iron Deficiency Anaemia Having Poor Response To Oral Iron Therapy2025
  3. 3Adherence to oral iron in adolescent females with iron deficiency secondary to heavy menstrual bleeding2025
  4. 4Role of Intravenous Iron in Current Era2024
  5. 5Impact of Intravenous Iron Therapy on Hospitalizations and Mortality in Patients with Heart Failure and Iron Deficiency: A Systematic Review and Meta-Analysis2024