Key result
Novel in vitro translation assay detects rhinovirus 3CD protease inhibition in native polyprotein form.
Population
In vitro translation assay for rhinovirus 3C protease inhibitors
Design
Preclinical
Authors
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May refine screening of rhinovirus 3C inhibitors; leaves open translation to cellular antiviral activity.
A new in vitro translation assay allows for qualitative and quantitative analysis of rhinovirus 3C protease inhibitors in their native polyprotein form.
Heinz et al. (1996) studied this question. A novel in vitro translation assay detects the inhibition of the rhinovirus 3CD protease in its native polyprotein form to evaluate compounds that demonstrate no antiviral activity.
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