Key result
Novel autoantibody targets hnRNP core polypeptides A2, B1, and B2 in SLE and Sjögren's syndrome.
Case Report (n=1)
Identifies a novel autoantibody targeting specific hnRNP core polypeptides (A2, B1, B2) in a patient with SLE and Sjögren's syndrome.
May prompt hnRNP reactivity testing in SLE/Sjögren overlap; leaves open prevalence and clinical utility pending validation.
A novel autoantibody reacting the the core polypeptides of hnRNP particles has been detected in the serum of a patient with systemic lupus erythematosus (SLE) and Sjögren's syndrome manifestations. Immunoblot analysis, using either rat liver or HeLa nuclear extracts as the antigen source, demonstrated that the autoantibody interacts with a specific subgroup of the core polypeptides of hnRNP particles, namely A2, B1 and B2, but not with A1, C1 and C2.
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Dangli et al. (1988) conducted a case report in Systemic lupus erythematosus (SLE) and Sjögren's syndrome (n=1). Autoantibodies to the core proteins of hnRNPs was evaluated on Interaction of autoantibody with specific subgroup of core polypeptides of hnRNP particles. A novel autoantibody reacting to the core polypeptides A2, B1, and B2 of hnRNP particles was detected in a patient with systemic lupus erythematosus and Sjögren's syndrome.
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