Key result
The postoperative period after CABG was associated with inhibition of paraoxonase, activation of myeloperoxidase, and enhanced arginase activity, which may predict postpericardiotomy syndrome.
Why the study?
The study was conducted to investigate the role of paraoxonase, myeloperoxidase, arginase, asymmetric dimethylarginine, and nitric oxide in the pathogenesis of postpericardiotomy syndrome after coronary artery bypass grafting.
Observational (n=76)
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Biomarkers of oxidative stress and endothelial dysfunction, such as myeloperoxidase and paraoxonase, may help predict the development of postpericardiotomy syndrome after coronary artery bypass grafting.
To study the role of paraoxonase, myeloperoxidase, arginase, asymmetric dimethylarginine, and nitric oxide in the mechanisms of the pathogenesis of postpericardiotomy syndrome (PPCS), 76 patients with ischemic heart disease (IHD) who underwent coronary artery bypass grafting were examined. Patients were divided into two groups: Group 1, IHD patients who were not diagnosed with PPCS as a result of clinical studies, and Group 2, IHD patients who were diagnosed with PPCS. The results indicate that the postoperative period after coronary artery bypass grafting is associated with the inhibition of paraoxonase, the activation of myeloperoxidase, enhanced arginase activity, increased nitrite/nitrate and asymmetric dimethylarginine levels; it may also be accompanied by the development of endothelial dysfunction and increased systemic inflammatory response. In the present work, inverse correlations were found between the paraoxonase aryl esterase activity and myeloperoxidase activity in plasma, as well as the paraoxonase aryl esterase activity in blood plasma and arginase activity in erythrocytes in patients of both groups. Tests to predict the development of postpericardiotomy syndrome were developed based on the ratio of activity of the studied enzymes.
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Внуков et al. (2019) conducted an observational in Ischemic heart disease and postpericardiotomy syndrome (n=76). Postpericardiotomy syndrome (PPCS) vs. No postpericardiotomy syndrome was evaluated on Enzyme activities (paraoxonase, myeloperoxidase, arginase) and nitric oxide system levels. The postoperative period after CABG was associated with inhibition of paraoxonase, activation of myeloperoxidase, and enhanced arginase activity, which may predict postpericardiotomy syndrome.
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