Key result
Screening of 353 samples from an age-banded serological cohort revealed a klassevirus seroprevalence of 6.8%, with seroconversion observed in 4 of 6 RT-PCR-positive individuals.
Cross-Sectional (n=359)
Yes
The study provides serological evidence that klassevirus infection and replication occur in humans, with a seroprevalence of 6.8% in a St. Louis cohort.
Supports human klassevirus exposure; leaves open clinical relevance and requires prospective validation.
Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.
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Greninger et al. (2010) conducted a cross-sectional in Klassevirus infection (n=359). Klassevirus exposure was evaluated on Seroprevalence. Screening of 353 samples from an age-banded serological cohort revealed a klassevirus seroprevalence of 6.8%, with seroconversion observed in 4 of 6 RT-PCR-positive individuals.
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