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Demonstrates resting membrane potential responses to ionic substitutions in cat papillary muscle, highlighting the role of potassium equilibrium.
The steady state transmembrane resting potential difference (V(m)) has been measured in quiescent papillary muscles. V(m) was determined as a function of the external K concentration in Cl and SO(4) solutions and compared with the K equilibrium potential. Other measurements were made after replacement of external Na by choline, K by Rb and Cs, and Cl by SO(4), CH(3)SO(4), and NO(3). Effects on V(m) of albumin, temperature, and variation in internal K concentration are described.
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Ernest W. Page (1962) studied this question.
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