Key result
Atrophic gastritis is linked to ~7% higher arterial stiffness in healthy middle-aged adults.
Why the study?
Does atrophic gastritis increase arterial stiffness in healthy middle-aged Japanese subjects?
Cross-Sectional (n=343)
Does atrophic gastritis increase arterial stiffness in healthy middle-aged Japanese subjects?
Absolute Event Rate: 16.63% vs 15.59%
p-value: p=0.010
Atrophic gastritis is associated with increased arterial stiffness in healthy middle-aged Japanese subjects, suggesting a potential link between gastric atrophy and atherosclerosis.
Should not change practice or prompt screening; leaves open whether atrophic gastritis contributes to atherosclerosis progression.
AIM: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. METHODS: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. RESULTS: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63+/-3.50 vs. 15.59+/-3.47 p=0.010, CAVIc; 8.59+/-1.20 vs. 8.27+/-1.19 p=0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. CONCLUSION: There may be an association between atrophic gastritis and atherosclerosis in middle-aged subjects.
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Torisu et al. (2009) conducted a cross-sectional in Arterial stiffness (n=343). Atrophic gastritis vs. No atrophic gastritis was evaluated on Adjusted brachial-ankle pulse wave velocity (baPWVc) (p=0.010). Atrophic gastritis was associated with significantly higher arterial stiffness, as measured by adjusted brachial-ankle pulse wave velocity (16.63 vs 15.59 m/sec, p=0.010), in healthy middle-aged Japanese subjects.
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