Key result
Higher gadolinium lipid payloads in HDL nanoparticles fail to increase relaxivity but enlarge particle size.
High payloads of gadolinium lipids in HDL nanoparticles maximize MR relaxivity at a molar fraction of 0.2, beyond which they induce significant conformational changes and increase particle size.
Optimal Gd loading at 0.2 molar fraction in HDL nanoparticles; leaves open in vivo validation before any clinical MRI translation.
High-density lipoprotein (HDL) nanoparticles doped with gadolinium lipids can be used as magnetic resonance imaging diagnostic agents for atherosclerosis. In this study, HDL nanoparticles with different molar fractions of gadolinium lipids (0 < xGd-lipids < 0.33) were prepared, and the MR relaxivity values (r1 and r2) for all compositions were measured. Both r1 and r2 parameters reached a maximal value at a molar fraction of approximately xGd-lipids = 0.2. Higher payloads of gadolinium did not significantly increase relaxivity values but induced changes in the structure of HDL, increasing the size of the particles from dH = 8.2 ± 1.6 to 51.7 ± 7.3 nm. High payloads of gadolinium lipids trigger conformational changes in HDL, with potential effects on the in vivo behavior of the nanoparticles.
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Ramos‐Cabrer et al. (2016) studied Atherosclerosis. High-density lipoprotein (HDL) nanoparticles doped with gadolinium lipids was evaluated on MR relaxivity values (r1 and r2) and particle size. Higher payloads of gadolinium lipids in HDL nanoparticles (molar fraction > 0.2) did not significantly increase relaxivity but increased particle size from 8.2 to 51.7 nm.
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