Key result
GdDO3A-functionalized LDL nanoparticles enhance atheroplaque MRI signal intensity in atherosclerosis mouse models.
Why the study?
A method for in vivo detection of atheroplaques using LDL particles functionalized with MRI contrast agents was developed to enhance imaging signal intensity.
Does GdDO3A-OA functionalized LDL particles improve MRI signal intensity of atheroplaques in atherosclerosis mouse models?
Does GdDO3A-OA functionalized LDL particles improve MRI signal intensity of atheroplaques in atherosclerosis mouse models?
GdDO3A-OA functionalized LDL particles can significantly enhance MRI signal intensity for in vivo detection of atheroplaques in mouse models.
May enable targeted atheroplaque MRI in mouse models; leaves open translation and safety in humans.
A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.
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Yamakoshi et al. (2011) studied this question. LDL-based nanoparticles functionalized with a GdDO3A-monoamide chelate significantly enhanced MRI signal intensity of atheroplaques in atherosclerosis mouse models.
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