Population
Wild type and apolipoprotein E-deficient mice fed a high-fat diet
Comparison
Globular domain of adiponectin coupled to… vs Fluorescent-labeled gAd
Design
Preclinical
Key result
Globular adiponectin-targeted liposomes accumulated at the plaque surface, whereas targeted proticles became internalized and showed spotted staining, enabling differential plaque imaging.
Authors
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May enable differential plaque imaging in animal models; leaves open clinical translation of adiponectin-targeted nanoparticles.
Adiponectin-coated nanoparticles offer a promising approach for enhanced imaging and targeted visualization of different regions within atherosclerotic plaques.
Prassl et al. (2011) studied Atherosclerosis. Globular adiponectin (gAd)-targeted nanoparticles (proticles and liposomes) vs. Fluorescent-labeled gAd was evaluated on Ex vivo imaging and characterization of atherosclerotic plaques. Globular adiponectin-targeted liposomes accumulated at the plaque surface, whereas targeted proticles became internalized and showed spotted staining, enabling differential plaque imaging.
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