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February 20, 2019ACS Applied Materials & Interfaces

Fe-PFH-PLGA/CS-DS nanoparticles selectively accumulated at SR-A sites on activated macrophages in apoE-/- mice, enabling MRI detection and LIFU-induced macrophage apoptosis.

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Population

In vitro activated macrophages and an ex vivo/in vivo atherosclerotic plaque model of apolipoprotein E…

Design

Preclinical

Key result

Fe-PFH-PLGA/CS-DS nanoparticles selectively accumulated at SR-A sites on activated macrophages in apoE-/- mice, enabling MRI detection and LIFU-induced macrophage apoptosis.

Authors

MYMan YeJZJun ZhouYZYixin Zhong

Discussion

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Overview

Preclinical SR-A–targeted PFH-DS nanoparticles enable plaque imaging and therapy; leaves open in vivo efficacy and clinical translation.

Structured PICO

P
Population
In vitro and ex vivo/in vivo models using apolipoprotein E knockout mice induced by high cholesterol to study atherosclerotic vulnerable plaques.
I
Intervention
Fe-PFH-poly(lactic-co-glycolic acid) (PLGA)/chitosan (CS)-dextran sulfate (DS) nanoparticles (NPs) combined with low-intensity focused ultrasound (LIFU) irradiation
O
Outcome
Nanoparticle phase transition for ultrasound imaging, MRI enhancement, macrophage binding/endocytosis, and induction of apoptosissurrogate

Fe-PFH-PLGA/CS-DS nanoparticles combined with low-intensity focused ultrasound show potential as multimodal probes for the specific diagnosis and targeted therapy of vulnerable atherosclerotic plaques in a preclinical model.

Cite This Study

Ye et al. (2019) studied Atherosclerotic vulnerable plaques. Fe-PFH-PLGA/CS-DS nanoparticles combined with low-intensity focused ultrasound (LIFU) was evaluated on Phase transition, MRI enhancement, macrophage apoptosis, and selective accumulation at SR-A sites. Fe-PFH-PLGA/CS-DS nanoparticles selectively accumulated at SR-A sites on activated macrophages in apoE-/- mice, enabling MRI detection and LIFU-induced macrophage apoptosis.

synapsesocial.com/papers/6aae528fc3c32c9acd0ccca8https://doi.org/10.1021/acsami.8b18190
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