Why the study?
Vulnerable atherosclerotic plaques cause most cardiovascular diseases, and folate receptor-positive activated macrophages are thought to be prominent in their development, prompting the development of targeted multimodal imaging nanoprobes.
Does Pd@Au-PEG-FA enable targeted multimodal imaging of folate receptors in advanced atherosclerotic plaques?
Does Pd@Au-PEG-FA enable targeted multimodal imaging of folate receptors in advanced atherosclerotic plaques?
Pd@Au-PEG-FA nanoprobes provide a targeted multimodal imaging approach for detecting high-risk atherosclerotic plaques via folate receptors in preclinical models.
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May enable folate-targeted plaque imaging in animal models; leaves open clinical translation pending human studies.
Guo et al. (2019) studied this question.
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