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September 20, 2023Frontiers in Bioengineering and BiotechnologyOpen Access

T1-weighted imaging of the carotid artery showed a progressive signal ratio increase between plaques and controls within 72 hours post-administration.

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Why the study?

Plaque rupture can lead to cerebral and myocardial infarction, underscoring the urgency of noninvasive early diagnosis using contrast-enhanced MRI.

Do PEGylated ultrasmall iron oxide nanoparticles improve noninvasive MRI and fluorescence imaging of atherosclerotic plaques in a preclinical model?

Comparison

Intravenous dual-modality magnetic resonance/fluorescence probe vs controls

Design

Preclinical imaging study

Follow-up

Within 72 h

Authors

RZRuru ZhangKLKuan LuXLXiao Li

Discussion

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Member takes

Overview

PEG-modified ultrasmall iron oxides may aid noninvasive MRI plaque detection; leaves open clinical translation and validation.

Structured PICO

Do PEGylated ultrasmall iron oxide nanoparticles improve noninvasive MRI and fluorescence imaging of atherosclerotic plaques in a preclinical model?

P
Population
Preclinical model of atherosclerosis (specific animal model not stated in abstract)
I
Intervention
Intravenous administration of PEGylated ultrasmall iron oxide nanoparticles (approximately 3 nm) as a dual-modality magnetic resonance/fluorescence probe
C
Comparator
Control tissues/regions
O
Outcome
Signal enhancement and lesion-to-control signal ratio on T1-weighted MRIsurrogate

PEGylated ultrasmall iron oxide nanoparticles show promise as a dual-modality probe for early, noninvasive, and dynamic MRI evaluation of atherosclerotic plaques.

Cite This Study

Zhang et al. (2023) studied this question.

synapsesocial.com/papers/6a70434726770c2b8de06bb5https://doi.org/10.3389/fbioe.2023.1279446
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Also Consider

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  1. 1Inflammatory-targeted iron oxide nanoparticles contrast agent for magnetic resonance imaging of atherosclerotic plaques2025
  2. 2Use of Ultrasmall Superparamagnetic Iron Oxide Particles for Imaging Carotid Atherosclerosis2015 · 24 citations
  3. 3Iron Oxide Particles for Atheroma Imaging2009 · 137 citations
  4. 4OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice2012 · 32 citations
  5. 5Engineered Biomimetic Iron Oxide Nanoparticles for Early MR Diagnosis and Intervention of Atherosclerotic Vulnerable Plaques2025