Key result
In human carotid tissue, 3'-aza-2'-[18F]fluorofolic acid selectively accumulated in atherosclerotic plaques by binding to FR-β-expressing macrophages, highlighting its potential for plaque imaging.
Selectively targeting FR-β-positive macrophages with folate-based radiopharmaceuticals like 3'-aza-2'-[18F]fluorofolic acid may enable noninvasive imaging of atherosclerotic plaque inflammation.
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May support targeted plaque imaging research; leaves open clinical translation and outcome impact in atherosclerosis.
Müller et al. (2014) studied Atherosclerotic plaque inflammation. 3'-aza-2'-[18F]fluorofolic acid vs. Normal artery walls was evaluated on FR-β and CD68 expression and radiotracer accumulation. In human carotid tissue, 3'-aza-2'-[18F]fluorofolic acid selectively accumulated in atherosclerotic plaques by binding to FR-β-expressing macrophages, highlighting its potential for plaque imaging.
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