Why the study?
Does 18F-FCH improve the detection of atherosclerotic plaques compared to 18F-FDG in apolipoprotein E-deficient mice?
Population
Atherosclerotic apolipoprotein E-deficient mice (n=13)
Comparison
18F-fluorocholine (18F-FCH) intravenous injection vs 18F-fluorodeoxyglucose intravenous injection
Design
Preclinical
Follow-up
20 minutes
Authors
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Hypothesis-generating for 18F-FCH in human plaque imaging; prospective clinical studies needed before adoption.
Does 18F-FCH improve the detection of atherosclerotic plaques compared to 18F-FDG in apolipoprotein E-deficient mice?
18F-FCH identifies murine atherosclerotic plaques better than 18F-FDG ex vivo, suggesting potential for clinical plaque imaging.
Matter et al. (2005) studied this question.
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