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September 1, 2011BiologicsOpen Access

Globular adiponectin binds more strongly to atherosclerotic plaques than full-length adiponectin subfractions, accumulating preferentially in endothelial cells and the fibrous cap area.

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Population

Aortas of wild-type and apoprotein E-deficient mice fed a high cholesterol diet

Comparison

Fluorescence-labeled recombinant mouse globular… vs Fluorescence-labeled subfractions of full-length…

Design

Preclinical

Authors

HMHarald ManggeSSaba-LepekHHaj-Yahya

Discussion

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Overview

Does not support clinical adoption for plaque imaging; leaves open further preclinical and human validation.

Structured PICO

P
Population
Aortas of wild-type and apoprotein E-deficient mice fed a high cholesterol diet
I
Intervention
Fluorescence-labeled recombinant mouse globular adiponectin (gAd)
C
Comparator
Fluorescence-labeled subfractions of full-length adiponectin (trimeric, hexameric, and oligomeric forms)
O
Outcome
Binding and visualization of atherosclerotic plaques using confocal laser scanning microscopysurrogate

Globular adiponectin demonstrates superior binding to atherosclerotic plaques compared to full-length adiponectin, highlighting its potential as a targeted molecular imaging agent for atherosclerosis.

Cite This Study

Mangge et al. (2011) studied this question.

synapsesocial.com/papers/6a70fbc98031ec7bb1dcb3b9https://doi.org/10.2147/btt.s22863
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adiponectin-coated nanoparticles for enhanced imaging of atherosclerotic plaques2011 · 33 citations
  2. 2Ultrastructural Localization of Adiponectin protein in Vasculature of Normal and Atherosclerotic mice2014 · 32 citations
  3. 3Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles2015 · 24 citations
  4. 4Lack of Association Between Adiponectin Levels and Atherosclerosis in Mice2010 · 63 citations
  5. 5Low Adiponectin Levels Are Associated With Atherogenic Dyslipidemia and Lipid-Rich Plaque in Nondiabetic Coronary Arteries2008 · 55 citations