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March 31, 2021Contrast Media & Molecular ImagingOpen Access

Hydrodenticity of cHANPs and Ab36-cHANPs is preserved in human atherosclerotic plaque, with preliminary evidence of interaction between these probes and the plaque.

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Why the study?

Current imaging modalities fail to identify patients at high risk of plaque rupture, and hydrogel nanoparticles encapsulating Gd-DTPA may enable active targeting for earlier, more accurate diagnosis.

Population

Human atherosclerotic plaque

Comparison

Ab36-cHANPs vs undecorated cHANPs

Design

In vitro experimental study

Authors

APAngela Costagliola di PolidoroAGAgnese GrassiaFSFrancesca Sarno

Discussion

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Overview

May support targeted MRI of vulnerable plaques; hypothesis-generating in animal models and requires human validation.

Structured PICO

P
Population
Human atherosclerotic plaque model
I
Intervention
Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) and anti-CD36 decorated cHANPs (Ab36-cHANPs) encapsulating Gd-DTPA
O
Outcome
Preservation of Hydrodenticity and interaction with atherosclerotic plaquesurrogate

Nanoparticle-based contrast agents utilizing hydrodenticity show promise for targeted MRI imaging of vulnerable atherosclerotic plaques.

Cite This Study

Polidoro et al. (2021) studied this question.

synapsesocial.com/papers/6a21e898c7675eb28596d89fhttps://doi.org/10.1155/2021/6664471
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