Key result
Engineered nanoparticles for intravascular imaging of atherosclerosis enable targeted detection of high-risk plaques and enhanced image contrast, with ongoing challenges for clinical translation.
Why the study?
Atherosclerosis causes high morbidity and mortality, requiring intravascular imaging techniques and nanoparticles to detect high-risk plaques, enhance contrast, and provide therapeutics.
This review highlights the potential and challenges of using engineered nanoparticles to enhance intravascular imaging for the targeted detection of high-risk atherosclerotic plaques.
Nanoparticle imaging remains investigational; leaves open clinical translation pending safety and efficacy trials.
Atherosclerosis is a leading cause of morbidity and mortality, and high-risk atherosclerotic plaques can result in myocardial infarction, stroke, and/or sudden death. Various imaging and sensing techniques (e.g., ultrasound, optical coherence tomography, fluorescence, photoacoustic) have been developed for scanning inside blood vessels to provide accurate detection of high-risk atherosclerotic plaques. Nanoparticles have been utilized in intravascular imaging to enable targeted detection of high-risk plaques, to enhance image contrast, and in some applications to also provide therapeutic functions of atherosclerosis. In this paper, we review the recent progress on developing nanoparticles for intravascular imaging of atherosclerosis. We discuss the basic nanoparticle design principles, imaging modalities and instrumentations, and common targets for atherosclerosis. The review is concluded and highlighted with discussions on challenges and opportunities for bringing nanoparticles into in vivo (pre)clinical intravascular applications.
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Li et al. (2023) conducted a review in Atherosclerosis. Engineered nanoparticles was evaluated. Engineered nanoparticles for intravascular imaging of atherosclerosis enable targeted detection of high-risk plaques and enhanced image contrast, with ongoing challenges for clinical translation.
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