Key result
Pretransplant abnormal vibration perception thresholds linked to ~101% greater pancreas graft failure and incident CVD.
Why the study?
Information regarding the impact of diabetic neuropathy on outcomes after pancreas transplantation was scarce.
Are abnormal vibration perception thresholds associated with worse graft outcomes and incident cardiovascular disease in patients with type 1 diabetes and end-stage kidney disease undergoing pancreas transplantation?
Cohort (n=187)
Are abnormal vibration perception thresholds associated with worse graft outcomes and incident cardiovascular disease in patients with type 1 diabetes and end-stage kidney disease undergoing pancreas transplantation?
Hazard Ratio: 2.01 (95% CI 1.01–4)
In patients with type 1 diabetes and end-stage kidney disease undergoing pancreas transplantation, abnormal vibration perception thresholds are independently associated with increased risk of graft failure and incident cardiovascular disease.
May flag higher-risk pancreas transplant candidates for closer monitoring; leaves open whether screening alters outcomes or warrants trials.
BACKGROUND: Information about the impact of diabetic neuropathy (DN) on outcomes after pancreas transplantation (PT) is scarce. We assessed the independent relationship between DN markers with both graft survival and incident cardiovascular disease (CVD) after transplantation. METHODS: A cohort study in individuals with type 1 diabetes and end-stage kidney disease who underwent PT between 1999 and 2015 was conducted. DN was assessed with vibration perception thresholds (VPTs) and orthostatic hypotension (pre-PT and 6 mo, 2-3, 5-6, and 8-10 y after transplantation). Pretransplantation and posttransplantation DN markers were related with graft failure/dysfunction and incident CVD during follow-up. RESULTS: We included 187 participants (70% men, age 39.9 ± 7.1 y, diabetes duration 27.1 y), with a median follow-up of 11.3 y. Abnormal VPTs (≥25 V) were observed in 53%. After transplantation, VPTs improved (22.4 ± 8.4 pretransplant versus 16.1 ± 6.1 V at 8-10 y post-PT; P < 0.001); additionally, the prevalence of abnormal VPTs decreased (53% pretransplant versus 24.4% at 8-10 y; P < 0.001). After adjusting for age, sex, diabetes duration, blood pressure, body mass index, and previous CVD, pretransplant VPTs ≥25 V were independently associated with pancreas graft failure/dysfunction (hazard ratio [HR], 2.01 [1.01-4.00]) and incident CVD (HR, 2.57 [1.17-5.64]). Furthermore, persistent abnormal VPTs after 6 mo posttransplantation were associated with the worst outcomes (HR, 2.80 [1.25-6.23] and HR, 3.19 [1.14-8.96], for graft failure/dysfunction and incident CVD, respectively). CONCLUSIONS: In individuals with type 1 diabetes and end-stage kidney disease, PT was associated with an improvement of VPTs. This simple and widely available DN study was independently associated with pancreas graft function and CVD posttransplantation.
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Boswell et al. (2022) conducted a cohort in Type 1 diabetes and end-stage kidney disease (n=187). Abnormal vibration perception thresholds (≥25 V) vs. Normal vibration perception thresholds (<25 V) was evaluated on Pancreas graft failure/dysfunction (HR 2.01, 95% CI 1.01-4.00). Pretransplant abnormal vibration perception thresholds (≥25 V) were independently associated with pancreas graft failure/dysfunction (HR 2.01; 95% CI 1.01-4.00) and incident CVD.
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