Combination therapy with three antiretroviral drugs improves the outcome of patients infected with human immunodeficiency virus type 1 (HIV-1) and has led to sustained decreases in AIDS-related morbidity and mortality in North America and Europe.13 Long-overdue attention has recently focused on providing this lifesaving therapy to persons with HIV-1 infection in developing countries.4 But even under ideal circumstances, current antiretroviral therapy has substantial limitations. Foremost among them are side effects of the medications and incomplete suppression of HIV-1 replication, which allows the emergence of drug-resistant variants of HIV-1.Antiretroviral therapy is most effective the first time it is prescribed. . . .
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Montaner et al. (2001) studied this question.
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