Key result
Higher pathogen burden, particularly enteroviruses and C. pneumoniae, is strongly linked to decreased insulin sensitivity.
Why the study?
Is burden of infection associated with insulin resistance in healthy middle-aged men?
Population
124 apparently healthy middle-aged men, hepatitis C virus antibody seronegative
Design
Cross-sectional
Authors
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Association in cross-sectional data is hypothesis-generating; prospective studies needed before any clinical implications.
Cross-Sectional (n=124)
Is burden of infection associated with insulin resistance in healthy middle-aged men?
Effect estimate: r = -0.71
p-value: p=<0.0001
Pathogen burden, particularly from enteroviruses and C. pneumoniae, is associated with insulin resistance in healthy middle-aged men, potentially mediated by chronic low-grade inflammation.
José Manuel Fernández‐Real (2006) conducted a cross-sectional in Healthy (n=124). Infection burden (HSV-1, HSV-2, enteroviruses, C. pneumoniae) was evaluated on Insulin sensitivity (r = -0.71, p=<0.0001). Higher pathogen burden, particularly seropositivity for enteroviruses (r = -0.71, P<0.0001) and C. pneumoniae, was significantly associated with decreased insulin sensitivity.
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