Key result
Gemcitabine chemotherapy is linked to acute non-Q-wave MI in a patient with underlying cardiac disease.
Why the study?
Does gemcitabine cause acute myocardial infarction in patients with underlying cardiac disease?
Case Report (n=1)
Does gemcitabine cause acute myocardial infarction in patients with underlying cardiac disease?
Gemcitabine may cause acute myocardial infarction and should be administered with caution in patients with underlying cardiac disease.
May warrant caution with gemcitabine in patients with cardiac disease; leaves open causality from this single case.
The objective of this paper is to report a case of acute, non-q-wave myocardial infarction, presumably secondary to gemcitabine chemotherapy for nonsmall cell lung cancer. A 43-year-old woman with postpartum cardiomyopathy and ischemic heart disease was treated with gemcitabine for metastatic nonsmall cell lung cancer. Three days after her 5th treatment with gemcitabine, she developed chest pain and was diagnosed as having acute, non-q-wave myocardial infarction. She made an uneventful recovery. An objective causality assessment revealed that the adverse event was possible. Gemcitabine has been previously reported to be causative of acute myocardial infarction. Ischemic complications of chemotherapeutic agents are discussed. A review of literature on this subject is presented. Gemcitabine should be administered with caution in patients with underlying cardiac disease.
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Bdair et al. (2006) conducted a case report in Metastatic nonsmall cell lung cancer (n=1). Gemcitabine was evaluated on Acute, non-q-wave myocardial infarction. Gemcitabine chemotherapy was associated with the development of an acute, non-q-wave myocardial infarction in a 43-year-old woman with underlying cardiac disease.
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