Key result
Quercetin potentiates Ca2+-insensitive 45Ca efflux in frog muscle fibers, an effect prevented by ATP removal.
Population
Segments of frog semitendinosus muscle skinned by microdissection
Comparison
Quercetin and ATP removal vs Control conditions
Design
Preclinical
Authors
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Skinned frog fiber data should not alter clinical practice; leaves open ATP regulation of sarcoplasmic reticulum Ca efflux channels.
ATP plays a fundamental role in the excitation of skinned muscle fibers by imposed diffusion potentials and may regulate the sarcoplasmic reticulum Ca efflux channel.
E W Stephenson (1985) studied this question. Quercetin and ATP removal vs. Control (unstimulated / ATP present) was evaluated on 45Ca efflux. In skinned frog muscle fibers, quercetin potentiated the Ca2+-insensitive component of stimulated 45Ca efflux, an effect that was prevented by ATP removal.
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