What question did this study set out to answer?

To describe the structural and cellular mechanisms by which the invariant chain guides MHC class II assembly, intracellular trafficking, and antigen loading.

February 1, 1996CellOpen Access

Invariant Chain Structure and MHC Class II Function

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Authors

PCPeter CresswellYale University

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Implication

Review outlines invariant chain regulation of MHC class II trafficking and peptide loading, highlighting mechanisms enabling antigen presentation to CD4+ T cells.

Key Points

To describe the structural and cellular mechanisms by which the invariant chain guides MHC class II assembly, intracellular trafficking, and antigen loading.
Review and synthesis of molecular and structural biology literature detailing invariant chain (Ii) interactions with MHC class II αβ dimers.
Evaluation of endosomal–lysosomal targeting, proteolytic processing, and HLA-DM/H2-M-mediated peptide exchange pathways.
Newly formed class II αβ dimers assemble as a nonameric complex with an invariant chain trimer in the endoplasmic reticulum, blocking premature peptide binding.
Targeting motifs in the invariant chain drive the complex to the endosomal–lysosomal pathway, where proteolysis leaves only the class II-associated invariant chain peptide (CLIP) bound to αβ dimers.
Interaction with HLA-DM (or mouse H2-M) ejects CLIP, permitting high-affinity binding of endosomal peptides prior to surface transport and CD4+ T cell engagement.

Cite This Study

Peter Cresswell (1996) studied this question.

synapsesocial.com/papers/6aa3e8d1e0a56e090ff437e5 https://doi.org/10.1016/s0092-8674(00)81025-9

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Implication

Review outlines invariant chain regulation of MHC class II trafficking and peptide loading, highlighting mechanisms enabling antigen presentation to CD4+ T cells.

Invariant Chain Structure and MHC Class II Function

Discussion

Member takes

Implication

Key Points

Cite This Study

Invariant Chain Structure and MHC Class II Function

Discussion

Member takes

Implication

Key Points

Cite This Study

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