Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-κB and Nrf2 pathways

Fang et al. (2019) studied Hyperoxic lung injury. ACE2 agonist diminazene aceturate (DIZE) or inhibitor MLN-4760 vs. Hyperoxia alone was evaluated on Severity of hyperoxic lung injury, inflammatory response, and oxidative stress. In adult mice, activation of ACE2 with diminazene aceturate attenuated hyperoxia-induced lung injury, inflammatory response, and oxidative stress by regulating NF-κB and Nrf2 pathways.