Key result
Epidural 0.75% ropivacaine plus 1% lidocaine improves blockade and reduces postoperative cognitive impairment versus lower doses.
Why the study?
To evaluate the effectiveness of epidural anaesthesia induced by different dosages of ropivacaine combined with lidocaine in geriatric orthopaedic surgery.
Does a higher dose of ropivacaine (0.75%) combined with 1% lidocaine improve blockade effects and cognitive outcomes compared to lower doses in elderly orthopaedic surgical patients?
RCT
Does a higher dose of ropivacaine (0.75%) combined with 1% lidocaine improve blockade effects and cognitive outcomes compared to lower doses in elderly orthopaedic surgical patients?
p-value: p=<0.05
Epidural anaesthesia combining 0.75% ropivacaine with 1% lidocaine in elderly orthopaedic patients provides rapid onset, long duration, and better cognitive outcomes without increasing adverse reactions.
May reduce early cognitive impairment in elderly patients; hypothesis-generating and requires RCTs before changing epidural practice.
Objective This paper unravelled the effectiveness of epidural anaesthesia induced by different dosages of ropivacaine combined with lidocaine in geriatric orthopaedic surgery. Methods Elderly orthopaedic surgical patients who underwent epidural anaesthesia were allocated into three groups: Group I (0.375% ropivacaine+1% lidocaine), Group II (0.50% ropivacaine+1% lidocaine) and Group III (0.75% ropivacaine+1% lidocaine), to compare the sensory and motor blockade effects, the occurrence of cognitive function and cognitive dysfunction, and the occurrence of adverse reactions. Results The onset time of sensory blockade and the appearance time of the highest plane were significantly earlier and the maintenance time of the highest plane was significantly longer, the onset time of motor blockade was notably earlier, the maintenance time of the highest plane was markedly longer, and the modified Bromage score was distinctly higher in Group II and Group III in comparison with Group I (p<0.05). The postoperative 12- and 24-h Mini-Mental State Examination scores were higher and the incidence of postoperative 12h-cognitive impairment was lower in Group III than in Group I and Group II (p<0.05). There was no statistically significant difference in the incidence of adverse reactions in patients among the three groups (p>0.05). Conclusions Epidural anaesthesia combining 0.75% ropivacaine with 1% lidocaine in elderly orthopaedic surgical patients has a rapid onset of action, a long duration of anaesthesia maintenance, a low overall impact on cognitive function, and good medication safety.
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Li et al. (2025) conducted an RCT in Geriatric orthopaedic surgery. 0.75% ropivacaine + 1% lidocaine vs. 0.375% or 0.50% ropivacaine + 1% lidocaine was evaluated on Sensory and motor blockade effects, cognitive function, and adverse reactions (p=<0.05). Epidural anaesthesia with 0.75% ropivacaine and 1% lidocaine improved sensory/motor blockade onset and duration, and reduced 12-hour postoperative cognitive impairment compared to lower doses (p<0.05).
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