Key result
Primary carnitine deficiency is linked to increased myocardial lipid deposition, lipid peroxidation, and SERCA2 sulfonylation.
Population
A 22-year-old woman with primary carnitine deficiency and ventricular fibrillation, and her first-degree…
Design
Case_report
Authors
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May link oxidative stress to dysfunction in carnitine deficiency; hypothesis-generating, should not change practice.
Case Report
Increased myocardial oxidative stress, evidenced by lipid peroxidation and SERCA2 sulfonylation, may contribute to myocardial dysfunction and arrhythmogenesis in primary carnitine deficiency.
Mazzini et al. (2011) conducted a case report in Primary carnitine deficiency. Primary carnitine deficiency was evaluated on Myocardial lipid deposition, lipid peroxidation, and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2. Primary carnitine deficiency demonstrated increased myocardial lipid deposition, lipid peroxidation, and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2.
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