[reaction: see text] The regioselective functionalization of 4,12-dibromoparacyclophane via electrophilic aromatic substitution is reported for the first time. The functionalization of the paracyclophane backbone allows the development of a new family of paracyclophane-based phosphines (named ParaPhos) that opens the possibility of improved catalyst development and tuning while retaining all the catalysis potential of the PhanePhos family of ligands.
No takes yet. Share an insight, caveat, or question.
Domínguez et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: