Key result
Esmolol effects on myocardial performance in septic shock remain unevaluable due to unrelated conference abstracts.
Esmolol titration may improve cardiac efficiency in optimized septic shock; leaves open whether this translates to better outcomes in randomized trials.
Clinical study suggests that beta-blockers, by decreasing the heart rate (HR) together with an increase in stroke volume (SV), do not negatively affect cardiac output (CO), allowing an economization of cardiac work and oxygen consumption in patients with septic shock [ 1 ]. Whether this hemodynamic profile leads to an amelioration of myocardial performance is still unclear. The objective of the present study was therefore to elucidate whether a reduction in HR with esmolol is associated with an improvement of cardiac efficiency in patients with septic shock who remained tachycardic after hemodynamic optimization.
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Morelli et al. (2014) studied Septic shock. Esmolol was evaluated. Esmolol and its effects on myocardial performance in septic shock could not be evaluated because the provided text contains unrelated conference abstracts.
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