What question did this study set out to answer?

To investigate the vascular mechanisms underlying recurrent angina episodes linked to elevated blood glucose levels in a patient with diabetes mellitus.

August 1, 1997Clinical CardiologyOpen Access

Hyperglycemia‐induced angina pectoris in a patient with diabetes mellitus

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Diabetes mellitus and coronary artery disease with recurring angina (n=1). Intervention: Hyperglycemia (glucose challenge) vs. Baseline (before glucose challenge). Primary outcome: Coronary microvascular responses (coronary flow reserve and responses to atrial pacing).

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Key result

Hyperglycemia impaired coronary microvascular responses and correlated with recurring episodes of angina in a patient with diabetes mellitus and coronary artery disease.

Why the study?

Does a glucose challenge impair coronary microvascular responses in a patient with diabetes mellitus and coronary artery disease?

Population

1 patient with diabetes mellitus and coronary artery disease presenting with recurring episodes of worsening…

Comparison

Glucose challenge during cardiac catheterization vs Baseline (before glucose challenge)

Design

Case_report

Authors

ALAlex LickermanUniversity of Chicago MGMaleah Grover‐McKayLong Beach Memorial Medical Center KDKevin C. DellspergerAugusta University

Discussion

Member takes

Implication

Acute hyperglycemia may provoke microvascular angina in diabetic CAD; single-case observation leaves open need for prospective confirmation before practice change.

Key Points

To investigate the vascular mechanisms underlying recurrent angina episodes linked to elevated blood glucose levels in a patient with diabetes mellitus.
Evaluated a single patient with diabetes mellitus and coronary artery disease who presented with worsening angina occurring specifically during episodes of hyperglycemia without angiographic changes.
Assessed coronary vascular dynamics, including coronary flow reserve and hemodynamics during atrial pacing, via cardiac catheterization using a Doppler flow wire before and after an acute glucose challenge.
Angina symptoms correlated clinically with episodes of acute hyperglycemia despite the absence of observable macrovascular angiographic changes.
Acute hyperglycemia directly impaired coronary microvascular responses and compromised coronary blood flow regulation following the glucose challenge.

Study Design

Type

Case Report (n=1)

Structured PICO

Does a glucose challenge impair coronary microvascular responses in a patient with diabetes mellitus and coronary artery disease?

Population

1 patient with diabetes mellitus and coronary artery disease presenting with recurring episodes of worsening angina.

Exposure

Glucose challenge during cardiac catheterization

Comparator

Baseline (before glucose challenge)

Outcome

Coronary vascular responses including coronary flow reserve and responses to atrial pacing measured with a Doppler flow wiresurrogate

Hyperglycemia can impair coronary microvascular responses and induce angina in patients with diabetes and coronary artery disease.

Cite This Study

Lickerman et al. (1997) conducted a case report in Diabetes mellitus and coronary artery disease with recurring angina (n=1). Hyperglycemia (glucose challenge) vs. Baseline (before glucose challenge) was evaluated on Coronary microvascular responses (coronary flow reserve and responses to atrial pacing). Hyperglycemia impaired coronary microvascular responses and correlated with recurring episodes of angina in a patient with diabetes mellitus and coronary artery disease.

synapsesocial.com/papers/6aa3ec2f647dfb68731aa05e https://doi.org/10.1002/clc.4960200814

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Implication

Acute hyperglycemia may provoke microvascular angina in diabetic CAD; single-case observation leaves open need for prospective confirmation before practice change.

Hyperglycemia‐induced angina pectoris in a patient with diabetes mellitus

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Hyperglycemia‐induced angina pectoris in a patient with diabetes mellitus

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider