What is the clinical evidence from this study?

Study design: Observational. Population: Transposition of the great arteries and intact ventricular septum (n=6). Intervention: Bidirectional cavopulmonary anastomosis and pulmonary artery banding. Primary outcome: Clinical outcomes (survival, neoaortic regurgitation, biventricular function).

What question did this study set out to answer?

To evaluate the efficacy and safety of combining bidirectional cavopulmonary anastomosis with pulmonary artery banding as an alternative left ventricular training strategy in patients with transposition of the great arteries and intact ventricular septum beyond the neonatal period.

January 25, 2019Congenital Heart Disease

A better approach for left ventricular training in transposition of the great arteries and intact interventricular septum: Bidirectional cavopulmonary anastomosis and pulmonary artery banding

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Why the study?

Management of patients with transposition of the great arteries and intact ventricular septum can be challenging beyond the newborn period, prompting an evaluation of an alternative strategy for left ventricular training.

Does bidirectional cavopulmonary anastomosis with pulmonary artery banding provide effective left ventricular training in patients with transposition of the great arteries and intact ventricular septum?

Comparison

Bidirectional cavopulmonary anastomosis with pulmonary artery banding followed by arterial switch operation

Design

Case series

Follow-up

Mean 20 months (9-32 months) following stage 2

Key result

Bidirectional cavopulmonary anastomosis with pulmonary artery banding allowed 4 of 6 patients to undergo anatomical repair, with all 4 surviving and demonstrating normal biventricular function at a mean 20-month follow-up.

Authors

MBMehmet Salih Bilal AÖArda Özyüksel MAM. Avsar

Discussion

Member takes

Overview

May support bidirectional cavopulmonary anastomosis with pulmonary artery banding for left ventricular training in transposition of the great arteries with intact ventricular septum; leaves open prospective validation.

Key Points

To evaluate the efficacy and safety of combining bidirectional cavopulmonary anastomosis with pulmonary artery banding as an alternative left ventricular training strategy in patients with transposition of the great arteries and intact ventricular septum beyond the neonatal period.
Evaluated 6 patients with transposition of the great arteries and intact ventricular septum, including 4 who underwent stage-1 bidirectional cavopulmonary anastomosis and pulmonary artery banding at the reporting institution.
Performed stage-2 anatomical repair via arterial switch operation with superior vena cava takedown and re-anastomosis to the right atrium in 4 patients after an interstage duration of 21 to 30 months.
All 4 patients who underwent stage-2 anatomical repair were discharged uneventfully without in-hospital mortality.
At a mean follow-up of 20 months (range, 9–32 months) post-stage 2, all patients demonstrated normal biventricular function and trivial neoaortic regurgitation.

Study Design

Type

Observational (n=6)

Multicenter

Yes

Structured PICO

Population

6 patients with transposition of the great arteries and intact ventricular septum undergoing left ventricle training, followed for a mean of 20 months after anatomical repair.

Exposure

Bidirectional cavopulmonary anastomosis in combination with pulmonary artery banding (stage-1) followed by arterial switch operation with takedown and direct re-anastomosis of the superior vena cava to right atrium (stage-2)

Outcome

Postoperative survival, neoaortic regurgitation, and biventricular functionhard clinical

Bidirectional cavopulmonary anastomosis with pulmonary artery banding may be a promising alternative strategy for left ventricle training in patients with transposition of the great arteries and intact ventricular septum.

Cite This Study

Bilal et al. (2019) conducted an observational in Transposition of the great arteries and intact ventricular septum (n=6). Bidirectional cavopulmonary anastomosis and pulmonary artery banding was evaluated on Clinical outcomes (survival, neoaortic regurgitation, biventricular function). Bidirectional cavopulmonary anastomosis with pulmonary artery banding allowed 4 of 6 patients to undergo anatomical repair, with all 4 surviving and demonstrating normal biventricular function at a mean 20-month follow-up.

synapsesocial.com/papers/6aa3ed678cc5e72c23b71db5 https://doi.org/10.1111/chd.12749

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January 25, 2019Congenital Heart Disease

A better approach for left ventricular training in transposition of the great arteries and intact interventricular septum: Bidirectional cavopulmonary anastomosis and pulmonary artery banding

View Full Paper

Ask AI

Bookmark

Why the study?

Comparison

Bidirectional cavopulmonary anastomosis with pulmonary artery banding followed by arterial switch operation

Design

Case series

Follow-up

Mean 20 months (9-32 months) following stage 2

Key result

Authors

MBMehmet Salih Bilal AÖArda Özyüksel MAM. Avsar

Discussion

Member takes

Overview

Key Points

To evaluate the efficacy and safety of combining bidirectional cavopulmonary anastomosis with pulmonary artery banding as an alternative left ventricular training strategy in patients with transposition of the great arteries and intact ventricular septum beyond the neonatal period.
Evaluated 6 patients with transposition of the great arteries and intact ventricular septum, including 4 who underwent stage-1 bidirectional cavopulmonary anastomosis and pulmonary artery banding at the reporting institution.
Performed stage-2 anatomical repair via arterial switch operation with superior vena cava takedown and re-anastomosis to the right atrium in 4 patients after an interstage duration of 21 to 30 months.
All 4 patients who underwent stage-2 anatomical repair were discharged uneventfully without in-hospital mortality.
At a mean follow-up of 20 months (range, 9–32 months) post-stage 2, all patients demonstrated normal biventricular function and trivial neoaortic regurgitation.

Study Design

Type

Observational (n=6)

Multicenter

Yes

Structured PICO

Population

6 patients with transposition of the great arteries and intact ventricular septum undergoing left ventricle training, followed for a mean of 20 months after anatomical repair.

Exposure

Outcome

Postoperative survival, neoaortic regurgitation, and biventricular functionhard clinical

Cite This Study

synapsesocial.com/papers/6aa3ed678cc5e72c23b71db5 https://doi.org/10.1111/chd.12749

View Full Paper

Ask AI

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