Key result
Long noncoding RNAs play crucial roles in the biological processes underlying the pathophysiology of nonalcoholic fatty liver disease, serving as potential novel therapeutic targets and diagnostic markers.
Why the study?
Although nonalcoholic fatty liver disease is the most common liver disease worldwide, its mechanism and pathophysiology remain unclear, while long noncoding RNAs may play a vital role in regulating biological functions in NAFLD.
Long noncoding RNAs are important regulators in the pathophysiology of NAFLD and represent potential novel therapeutic targets and diagnostic biomarkers.
Supports lncRNA exploration in NAFLD; leaves open clinical adoption pending prospective validation.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, but its mechanism and pathophysiology remain unclear. Long noncoding RNAs (lncRNAs) may exert a vital influence on regulating various biological functions in NAFLD. METHODS: The databases such as Google Scholar, PubMed, and Medline were searched using the following keywords: nonalcoholic fatty liver disease, nonalcoholic fatty liver disease, NAFLD, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis, NASH, long noncoding RNAs, and lncRNAs. Considering the titles and abstracts, unrelated studies were excluded. The authors evaluated the full texts of the remaining studies. RESULTS: We summarized the current knowledge of lncRNAs and the main signaling pathways of lncRNAs involved in NAFLD explored in recent years. As a heterogeneous group of noncoding RNAs (ncRNAs), lncRNAs play crucial roles in biological processes underlying the pathophysiology of NAFLD. The mechanisms, particularly those associated with the regulation of the expression and activities of lncRNAs, play important roles in NAFLD. CONCLUSION: A better comprehension of the mechanism controlled by lncRNAs in NAFLD is necessary for the identification of novel therapeutic targets for drug development and improved, noninvasive methods for diagnosis.
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Shi et al. (2023) conducted a review in Nonalcoholic fatty liver disease (NAFLD). Long noncoding RNAs (lncRNAs) was evaluated on Role and mechanisms of lncRNAs in NAFLD pathophysiology. Long noncoding RNAs play crucial roles in the biological processes underlying the pathophysiology of nonalcoholic fatty liver disease, serving as potential novel therapeutic targets and diagnostic markers.
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