Key result
Rapid ~68-fold postoperative GH elevation may signal lethal complications earlier than established predictors.
Why the study?
Does rapid postoperative onset of raised plasma growth hormone concentration predict postoperative complications earlier than established markers?
Case Report (n=14)
Does rapid postoperative onset of raised plasma growth hormone concentration predict postoperative complications earlier than established markers?
Answers are grounded in this paper and cite their sources.
Rapid postoperative elevation of plasma growth hormone may serve as an early marker for postoperative complications.
SUMMARYWe compared the onset of predictors for postoperative complications (lactate, total T3 (tT3), total T4 (tT4) and cortisone) retrospectively with the onset of altered growth hormone (GH) concentration in a patient who had had a lethal postoperative outcome and in 13 patients who were without postoperative complications for a period of 24 hours postoperatively.Compared with the values of the patients without postoperative complications, GH values were elevated (68-fold) 1 h after surgery to 103 ng/ml and lactate was increased (12-fold) to 12.7 mmol/l at 6 h postoperatively in the patient with the lethal outcome. The other parameters measured (tT3, tT4 and cortisone) showed no rapid alteration during the first hours postoperatively.This case report suggests that the rapid postoperative onset of raised GH concentration in plasma may be an earlier marker for postoperative complications than the 'established' predictors.
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Rümelin et al. (2001) conducted a case report in Postoperative complications (n=14). Altered plasma growth hormone (GH) levels vs. Patients without postoperative complications was evaluated on Postoperative complications. Rapid postoperative elevation of plasma growth hormone (68-fold increase to 103 ng/ml at 1 hour) may serve as an earlier marker for lethal postoperative complications than established predictors.
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