Key result
Postoperative 12-hour lactate ≥1.35 mmol/L linked to ~2.6-fold higher complication risk after major abdominal surgery.
Why the study?
The prognostic value of early postoperative lactate levels for complications, mortality, and hospital stay after elective major abdominal surgery was unclear.
Does postoperative lactate level predict postoperative complications and mortality in adult patients undergoing elective major abdominal surgery?
Population
195 patients undergoing elective major abdominal surgery
Comparison
Lactate levels at different postoperative time points and their association with outcomes
Design
Prospective cohort study
Follow-up
Until discharge or death
Authors
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Elevated L12 lactate may stratify complication risk after major abdominal surgery; leaves open whether targeted interventions improve outcomes.
Cohort (n=195)
No
Does postoperative lactate level predict postoperative complications and mortality in adult patients undergoing elective major abdominal surgery?
Odds Ratio: 2.58 (95% CI 1.27–5.24)
p-value: p=0.001
Postoperative lactate levels at 12 hours independently predict postoperative complications and mortality after elective major abdominal surgery, even at thresholds typically considered normal.
Veličković et al. (2018) conducted a cohort in Elective major abdominal surgery (n=195). Serum lactate levels 12 hours postoperatively (L12 ≥ 1.35 mmol/L) vs. L12 < 1.35 mmol/L was evaluated on Postoperative complications (OR 2.58, 95% CI 1.27-5.24, p=0.001). Serum lactate levels ≥ 1.35 mmol/L measured 12 hours after elective major abdominal surgery independently predicted an increased risk of postoperative complications (OR 2.58).
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