Key result
Severe peripheral neuropathy did not alter the long-range temporal correlations in stride times compared to matched controls (P=0.954 and P=0.974), despite slower gait speeds (P=0.008).
Why the study?
Does severe peripheral neuropathy alter the long-range correlations in stride intervals of human gait compared to healthy controls?
Population
14 patients with severe peripheral neuropathy and 12 gender-, age-, height-, and weight-matched nondiabetic…
Comparison
Walking around an approximately 200-m open-level… vs 12 gender-, age-, height-, and weight-matched…
Design
Case-control
Follow-up
10 minutes
Authors
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Supports central regulation of gait dynamics; extends observations to severe neuropathy but remains hypothesis-generating.
Case-Control (n=26)
Does severe peripheral neuropathy alter the long-range correlations in stride intervals of human gait compared to healthy controls?
p-value: p=0.954 and 0.974
Severe peripheral sensory loss does not alter the normal long-range correlation structure of stride intervals, suggesting the central nervous system regulates these dynamics.
Gates et al. (2006) conducted a case-control in Severe peripheral neuropathy (n=26). Severe peripheral neuropathy vs. Nondiabetic controls was evaluated on Temporal correlations in stride times (power spectral density and detrended fluctuation analyses) (p=0.954 and 0.974). Severe peripheral neuropathy did not alter the long-range temporal correlations in stride times compared to matched controls (P=0.954 and P=0.974), despite slower gait speeds (P=0.008).
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