What is the clinical evidence from this study?

Population: experimental metabolic syndrome (n=24). Intervention: alcohol-free Alibernet red wine extract (AWE) vs. control. Primary outcome: total NOS activity and eNOS, iNOS and NFκB (p65) protein expressions.

January 1, 2014Food & Function

Red wine extract decreases pro-inflammatory markers, nuclear factor-κB and inducible NOS, in experimental metabolic syndrome

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Key result

Alcohol-free red wine extract reduces LV and aortic NFκB and iNOS in metabolic syndrome rats.

n=24

Why the study?

Does alcohol-free Alibernet red wine extract decrease pro-inflammatory markers in an experimental rat model of metabolic syndrome?

Structured PICO

Does alcohol-free Alibernet red wine extract decrease pro-inflammatory markers in an experimental rat model of metabolic syndrome?

Population

24 young 6-week-old male Wistar Kyoto and obese, spontaneously hypertensive rats with experimental metabolic syndrome, treated for 3 weeks.

Intervention

Alcohol-free Alibernet red wine extract (AWE) 24.2 mg/kg/day for 3 weeks

Comparator

Untreated control groups

Outcome

Total nitric oxide synthase (NOS) activity and endothelial NOS (eNOS), inducible NOS (iNOS), and nuclear factor-κB (NFκB) protein expressions in the heart left ventricle and aortasurrogate

Alibernet red wine extract reduces pro-inflammatory markers NFκB and iNOS in the cardiovascular system of rats with experimental metabolic syndrome, suggesting protective anti-inflammatory properties.

Discussion

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Implication

Supports anti-inflammatory effects in metabolic syndrome rat model; hypothesis-generating, leaves open human translation.

Cite This Study

Janega et al. (2014) studied experimental metabolic syndrome (n=24). alcohol-free Alibernet red wine extract (AWE) vs. control was evaluated on total NOS activity and eNOS, iNOS and NFκB (p65) protein expressions. Alcohol-free Alibernet red wine extract (24.2 mg/kg/day) decreased NFκB and iNOS protein expressions in the left ventricle and aorta of rats with experimental metabolic syndrome.

synapsesocial.com/papers/6aa40140c715cee61e21e424 https://doi.org/10.1039/c4fo00097h

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Red wine extract decreases pro-inflammatory markers, nuclear factor-κB and inducible NOS, in experimental metabolic syndrome

Structured PICO

Discussion

Implication

Cite This Study

Red wine extract decreases pro-inflammatory markers, nuclear factor-κB and inducible NOS, in experimental metabolic syndrome

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider