Key result
Total serum osteocalcin inversely correlates with mid-thigh adipose tissue distribution and serum insulin.
Why the study?
The relationship between osteocalcin levels and the distribution of different adipose tissue types, including subcutaneous, intermuscular, and visceral adipose tissue, remains unclear.
Cross-Sectional (n=128)
Effect estimate: cc = -0.29
p-value: p=0.002
Total serum osteocalcin is negatively correlated with the relative distribution of subcutaneous to intramuscular adipose tissue in the mid-thigh, supporting the negative influence of intramuscular adipose tissue on glucose metabolism.
May link osteocalcin to mid-thigh fat distribution and insulin; hypothesis-generating and requires longitudinal studies before clinical relevance.
Osteocalcin, in its non-carboxylated form, has a positive effect on glucose metabolism. Additionally, osteocalcin levels are related to body composition, especially muscle mass. The relation to the distribution of different adipose tissue types, such as subcutaneous, intermuscular, and visceral adipose tissue, is unclear. This study aimed to investigate associations between serum osteocalcin and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh. Furthermore, the influence of different training methods on osteocalcin levels was investigated. We performed adipose tissue quantification of subcutaneous adipose tissue (SAT) and intramuscular adipose tissue (IMAT) using MRI measurements of the mid-thigh in 128 volunteers (63 male/65 female). Laboratory analysis included blood lipid panel, serum insulin, adiponectin, and osteocalcin measurements. The main observation was a significant correlation of total serum osteocalcin (TOC) and the distribution of adipose tissue of the mid-thigh (SAT/(SAT + IMAT)) (cc = −0.29/p-value = 0.002), as well as the cross-sectional muscle area (MA), increasing with the weekly resistance training duration in males. Additionally, TOC (p-value = 0.01) and MA (p-value = 0.03) were negatively related to serum insulin. The significant relationship between TOC and SAT/(SAT + IMAT) is a new finding and confirms the negative influence of IMAT on glucose metabolism in a sex-specific approach. We could substantiate this by the negative relation of TOC with serum insulin.
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Hassler et al. (2021) reported a cross-sectional. Total serum osteocalcin was evaluated on Correlation of total serum osteocalcin (TOC) and the distribution of adipose tissue of the mid-thigh (SAT/(SAT + IMAT)) (cc = -0.29, p=0.002). Total serum osteocalcin was significantly negatively correlated with the distribution of mid-thigh adipose tissue (cc = -0.29, p=0.002) and serum insulin (p=0.01).
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